SAINT® Depression
Therapy

SAINT offers a new path to relief from depression: the first FDA-cleared treatment proven to bring rapid remission in just five days.

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WHY SAINT

Proven results, genuine hope, and a new way forward.

SAINT is here to change the timeline for recovery, offering a new path grounded in precision science and proven to deliver rapid remission from depression.

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Rapid remission

Clinical trials show a 79% remission rate in just 5 days of treatment, significantly shortening the road to lasting recovery.

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Personalized treatment

SAINT uses fMRI-guided targeting to map unique brain circuitry, ensuring a precise and tailored approach that is not one-size-fits-all.

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Relief without medication

SAINT is a noninvasive therapy designed to target the brain’s neural circuitry without the use of medication.

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Noninvasive outpatient therapy

The treatment delivers gentle, well tolerated magnetic pulses to the brain without requiring anesthesia or invasive surgery.

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Scientific rigor

Our precision treatment is built on groundbreaking science, giving people a proven path forward with unparalleled confidence.

HOW SAINT WORKS

Treating depression in days, not weeks.

SAINT is an advanced, targeted form of TMS therapy that uses precision neuromodulation to deliver rapid and lasting remission from Major Depressive Disorder (MDD) in an accelerated, 5-day treatment.

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Meet with a Verified SAINT Provider to determine if SAINT is the right treatment for you.

Homepage_HowItWorks_Consultation

The fMRI scan creates a unique map of your brain’s neural circuitry in about 45 minutes, allowing SAINT to target your depression precisely.

Homepage_HowItWorks_Brain Mapping

Our targeting algorithm uses the brain scan to map out the perfect location to deliver effective stimulation and treat your depression more precisely.

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SAINT TMS treatment takes just five days. Each day consists of ten 10-minute sessions per day, with 50-minute breaks in between. Most people begin to feel a change in their mood within just a couple of days.

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THE FACTS

SAINT helps people get better, faster.

Unlike conventional treatments that can take weeks or months to start working, SAINT can bring remission from depression symptoms in days.

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days of noninvasive, non-drug treatment (versus 6-9 weeks for standard TMS).

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of trial participants entered remission from their depression.

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days to remission on average instead of weeks or months.

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clinic visits (versus 30-36 for standard TMS)

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days of noninvasive, non-drug treatment (versus 6-9 weeks for standard TMS).

0 %

of trial participants entered remission from their depression.

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days to remission on average instead of weeks or months.

0

clinic visits (versus 30-36 for standard TMS)

Cole EJ, Stimpson KH, Bentzley BS, et al.: Stanford Accelerated Intelligent Neuromodulation Therapy for treatment-resistant depression. Am J Psychiatry 2020; 177:716–726 2.Cole EJ, Phillips AL, Bentzley, BS, et al.: Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial. Am J Psychiatry 2022; 179:2, 132–141.

“SAINT removed the depression I carried for years. It did not erase my problems; it changed how my brain responds to them. That change is the difference between “barely coping” and actually living my life.”

Alan S.

SAINT Patient

“I’m a scientist, I’m skeptical of a lot of things. And I don’t believe there’s any magic wand. We have to be really careful about how we interpret things, but SAINT is the closest thing I’ve seen to that magic wand.”

Mohammed Ahmed, MD

Clinical Director, Salma Health

“A few days after I started the treatment…. I went out walking and shopping. Music sounded a little sweeter. I got hungry, which for me is a good sign because I have a hard time eating when I feel depressed or anxious. You feel changes the week you do the treatment.”

Caroline N.

SAINT Patient

“There’s always been a concern that if it works fast, maybe it doesn’t work very well. But here we had a wonderful confluence of strong data showing that not only did people get their treatment done in a very short period of time, but that they had a very high probability of getting not just well, not just to response – but actually to remission.”

Ian Cook, MD, DLFAPA

Founding Director & CEO, Los Angeles TMS Institute

“Because of SAINT, my daughter’s depression became so much less dangerous, the suicidal ideation has disappeared, and she hasn’t taken any antidepressants since. I believe this technology is the best, and I think more people need to know about it. This could be the best solution we have to cure MDD.”

Sherri R.

Mother of a SAINT Patient
TESTIMONIALS

What people are saying about SAINT

Discover how science and compassion come together through the voices of patients and clinicians who’ve experienced SAINT firsthand.

“SAINT removed the depression I carried for years. It did not erase my problems; it changed how my brain responds to them. That change is the difference between “barely coping” and actually living my life.”

Alan S.

SAINT Patient

“I’m a scientist, I’m skeptical of a lot of things. And I don’t believe there’s any magic wand. We have to be really careful about how we interpret things, but SAINT is the closest thing I’ve seen to that magic wand.”

Mohammed Ahmed, MD

Clinical Director, Salma Health

“A few days after I started the treatment…. I went out walking and shopping. Music sounded a little sweeter. I got hungry, which for me is a good sign because I have a hard time eating when I feel depressed or anxious. You feel changes the week you do the treatment.”

Caroline N.

SAINT Patient

“There’s always been a concern that if it works fast, maybe it doesn’t work very well. But here we had a wonderful confluence of strong data showing that not only did people get their treatment done in a very short period of time, but that they had a very high probability of getting not just well, not just to response – but actually to remission.”

Ian Cook, MD, DLFAPA

Founding Director & CEO, Los Angeles TMS Institute

“Because of SAINT, my daughter’s depression became so much less dangerous, the suicidal ideation has disappeared, and she hasn’t taken any antidepressants since. I believe this technology is the best, and I think more people need to know about it. This could be the best solution we have to cure MDD.”

Sherri R.

Mother of a SAINT Patient

Featured resources

Discover the science, clinical data, and patient success stories that show the power of SAINT depression therapy.

All research
Our blog
blog
Patients & Families
A Veteran’s 5-Day Path to Remission with SAINT®
At Magnus Medical, we meet many people who have spent years fighting depression. Among them are vete…
research
MDD
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial
American Journal of Psychiatry | Volume 179, Issue 2
research
MDD
12 Months Sustained Remission from Depression using Personalized Continuation Therapy with SAINT®
Magnus Medical
blog
Patients & Families
Searching for Alternatives to Antidepressants? A New Option for Treatment-Resistant Depression
For many, traditional antidepressants don’t provide lasting relief from major depression. A new, non…

Find a SAINT® provider

The path to feeling better is here. Find a Verified SAINT Provider near you.

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Bring SAINT to your practice

Frequently asked questions

  • SAINT is an accelerated form of transcranial magnetic stimulation (TMS), but has some key differences.

    • Speed: SAINT condenses treatment into only 5 days, versus 6–9 weeks with conventional TMS. On average, participants reached remission in just 2.6 days rather than 3.5 weeks.
    • Personalization: SAINT is the only FDA-cleared depression treatment that uses functional MRI (fMRI) brain imaging to identify a personalized target for stimulation to treat major depression.
    • Precision: The combination of the fMRI, a personalized target, and neuronavigation enable SAINT to use best-in-class precision targeting.
    • Effectiveness: With over 400 patients treated in clinical trials, SAINT relieved symptoms for 85% of participants, with no serious adverse events.

  • Insurance coverage for SAINT is currently limited but we are working to expand it.

    • Medicare Fee-for-Service (FFS):
      Approved for payment at Verified SAINT Provider hospital sites.
    • Medicare Advantage (MA), Commercial, and Medicaid Plans:
      Coverage is determined on a case-by-case basis through the prior authorization process. Your provider can assist in submitting the necessary documentation and requesting approval from your insurer.
    • Out-of-Pocket:
      Self-pay options are available. Pricing and payment plans vary by site, so please contact your preferred treatment provider directly for details.

  • Candidates for SAINT are adults that have been diagnosed with Major Depressive Disorder and medications like antidepressants have not helped.

    Please contact a verified SAINT location to meet with a physician regarding your eligibility.

  • SAINT treatment is generally well-tolerated. The most commonly reported side effects are mild headache and temporary scalp irritation at the treatment site. Your SAINT provider will assist you in resolving any discomfort experienced during your treatment.