Reach real remission

SAINT® Depression Therapy is a breakthrough approach helping people living with depression find rapid, lasting relief without medication.

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why saint

Proven results, genuine hope, and a new way forward.

SAINT is here to change the timeline for recovery, offering a new path grounded in precision science and proven to deliver rapid remission from depression.

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Rapid remission

Clinical trials show a 79% remission rate in just 5 days of treatment, significantly shortening the road to lasting recovery.

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Personalized treatment

SAINT uses fMRI-guided targeting to map unique brain circuitry, ensuring a precise and tailored approach that is not one-size-fits-all.

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Relief without medication

SAINT is a noninvasive therapy that targets the brain’s neural circuitry without relying on medication.

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Noninvasive outpatient therapy

The treatment delivers gentle, well tolerated magnetic pulses to the brain without requiring anesthesia or invasive surgery.

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Scientific rigor

Our precision treatment is built on groundbreaking science, giving people a proven path forward with unparalleled confidence.

SAINT
90%
2.6 days
ECT
48%
3 weeks
TMS
17-32%
3.5 weeks
Esketamine
16-37%
15 months
Medication
14%
6-12 weeks

Data are shown for open-label studies in moderately to severely treatment-resistant depression. References: Cole et al 2020 (SAINT), Heijnen et al 2010 (ECT), Thirthalli et al 2020 (ECT), Blumberger et al 2018 (TMS 32%), Hsu et al 2019 (TMS 17)%; Janik et al 2025 (Esketamine 16%) Marton et al 2024 (Esketamine 37%, time to remission); Zaki et al 2025 (Esketamine treatment window); Sub-analysis of Blumberger participants with similar treatment resistance to SAINT patients), Rush et al 2006 (pharmacotherapy), Liu et al 2021 (pharmacotherapy, treatment window).

HOW SAINT WORKS

Treating depression in days, not weeks.

SAINT is an advanced, targeted form of TMS therapy that uses precision neuromodulation to deliver rapid and lasting remission from Major Depressive Disorder (MDD) in an accelerated, 5-day treatment.

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Meet with a Verified SAINT Provider to determine if SAINT is the right treatment for you.

The fMRI scan creates a unique map of your brain’s neural circuitry in about 45 minutes, allowing SAINT to target your depression precisely.

Our targeting algorithm uses the brain scan to map out the perfect location to deliver effective stimulation and treat your depression more precisely.

SAINT TMS treatment takes just five days. Each day consists of ten 10-minute sessions per day, with 50-minute breaks in between. Most people begin to feel a change in their mood within just a couple of days.

Precision depression treatment, explained.

Learn how SAINT uses advanced brain mapping to personalize treatment and deliver remission faster than other treatment options.
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Featured resources

Discover the science, clinical data, and patient success stories that show the power of SAINT depression therapy.

All research
Our blog
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Patients & Families
A Veteran’s 5-Day Path to Remission with SAINT®
At Magnus Medical, we meet many people who have spent years fighting depression. Among them are vete…
blog
Patients & Families
When Antidepressants Don’t Work, Five Days Could Change That
For many, traditional antidepressants don’t provide lasting relief from major depression. A new, non…
blog
Medical Professionals
A New Paradigm for Treating ‘Treatment-Resistant’ Depression
Contemporary research on the human brain is shedding new light on how to treat illnesses like depres…
blog
Medical Professionals
Tackling Depression: A New Treatment Offers Hope for Those Hardest to Treat
The growing need for mental health services is “the next pandemic” according to the American Hospita…
TESTIMONIALS

SAINT success stories

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“It’s lifesaving and life-changing. It’s not a cure, it’s a therapy, and it’s a much more effective way of treating the brain compared to any kind of medication. Doctors, people suffering from severe depression and their families need to know about SAINT and that it really is effective. The amount of time someone’s been depressed doesn’t really matter—it works.”

Dierdre L.

SAINT Patient
Read her story
“I had barely been able to hang out with my twin sister before SAINT. Afterward, I had the motivation and desire to spend time with my friends. I hadn’t felt a desire or the energy to hang out with another person in such a long time. I was shocked and surprised in a good way. I had improved so quickly.”

Chase E.

SAINT Patient
“SAINT removed the depression I carried for years. It did not erase my problems; it changed how my brain responds to them. That change is the difference between “barely coping” and actually living my life.”

Alan S.

SAINT Patient
Read his story

Frequently asked questions

  • SAINT is an accelerated form of transcranial magnetic stimulation (TMS), but has some key differences.

    • Speed: SAINT condenses treatment into only 5 days, versus 6–9 weeks with conventional TMS. On average, participants reached remission in just 2.6 days rather than 3.5 weeks.
    • Personalization: SAINT is the only FDA-cleared depression treatment that uses functional MRI (fMRI) brain imaging to identify a personalized target for stimulation to treat major depression.
    • Precision: The combination of the fMRI, a personalized target, and neuronavigation enable SAINT to use best-in-class precision targeting.
    • Effectiveness: With over 400 patients treated in clinical trials, SAINT relieved symptoms for 85% of participants, with no serious adverse events.

  • Insurance coverage for SAINT is currently limited but we are working to expand it.

    • Medicare Fee-for-Service (FFS):
      Approved for payment at Verified SAINT Provider hospital sites.
    • Medicare Advantage (MA), Commercial, and Medicaid Plans:
      Coverage is determined on a case-by-case basis through the prior authorization process. Your provider can assist in submitting the necessary documentation and requesting approval from your insurer.
    • Out-of-Pocket:
      Self-pay options are available. Pricing and payment plans vary by site, so please contact your preferred treatment provider directly for details.

  • Candidates for SAINT are adults that have been diagnosed with Major Depressive Disorder and medications like antidepressants have not helped.

    Please contact a verified SAINT location to meet with a physician regarding your eligibility.

  • SAINT treatment is generally well-tolerated. The most commonly reported side effects are mild headache and temporary scalp irritation at the treatment site. Your SAINT provider will assist you in resolving any discomfort experienced during your treatment.

Find SAINT® near you

Feeling better starts with finding the right care. Find a Verified SAINT Provider near you.

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